CYCELRION THERAPEUTICS, INC.
301 Binney Street
Cambridge, MA 02142
August 12, 2020
Securities and Exchange Commission
Division of Corporation Finance
100 F Street, N.E.
Washington, D.C. 20549
Attention: Margaret Schwartz
|Re:||Cyclerion Therapeutics, Inc. (the “Company”)|
|Registration Statement on Form S-3|
|File No. 333-242334|
Ladies and Gentlemen:
Pursuant to Rule 461 under the Securities Act of 1933, as amended, the Company hereby requests acceleration of the effective date of the above referenced Registration Statement to 4:00 p.m., Eastern time, on August 14, 2020, or as soon thereafter as practicable, or at such other time as the Company or its outside counsel, Hughes Hubbard & Reed LLP, request by telephone that such Registration Statement be declared effective.
Please contact Gary J. Simon, of Hughes Hubbard & Reed LLP, special counsel to the Company, at (212) 837-6770, as soon as the Registration Statement has been declared effective, or if you have any other questions or concerns regarding this matter.
|Very truly yours,|
|CYCLERION THERAPEUTICS, INC.|
|By:||/s/ William I. Huyett|
|Name:||William I. Huyett|
|Title:||Chief Financial Officer|
|cc: Hughes Hubbard & Reed LLP|