Cyclerion Therapeutics to Present Data on its Sickle Cell Disease Program at Upcoming Medical and Scientific Meetings
– In preclinical study, treatment with company’s investigational sGC stimulator olinciguat was associated with improved blood flow and reduced inflammation in a model of sickle cell disease –
– New research supports the need for a novel patient-reported outcome (PRO) instrument to measure sickle cell disease symptoms from the patient perspective –
“We continue to build a body of evidence to support the advancement of our sGC stimulator olinciguat, which we believe has the potential to be a life-changing medicine for patients with sickle cell disease,” said
Cyclerion is focused on unlocking the full therapeutic potential of the nitric oxide-cyclic guanosine monophosphate (cGMP) signaling pathway, a clinically validated pathway with potential for therapeutic applications in a wide range of cardiovascular, metabolic, inflammatory, fibrotic and neurological diseases. sGC is a key node in this pathway, and Cyclerion’s targeted sGC stimulators are designed to enhance pathway signaling in the tissues of greatest relevance to the diseases each is intended to treat. Olinciguat is Cyclerion’s investigational sGC stimulator designed to target the vasculature.
Cyclerion’s Upcoming SCD Presentations:
- Cyclerion will present a brief overview of olinciguat, its investigational treatment for sickle cell disease, and an update on the ongoing Phase 2 STRONG SCD study during the Investigational New Drug, Therapeutic, and Device Symposium.
Bina Tejura, Senior Medical Director, Cyclerion Friday, June 7, 4:30-6:30 p.m. EDT
- Location: Caribbean IV – V
- Cyclerion will sponsor “Men Living Well with Sickle Cell,” a pre-FSCDR town hall, in collaboration with FSCDR, BlackDoctor.org, and
Sickle Cell Association of Houston. Thursday, June 6, 7:00 p.m. EDT
Fort Lauderdale Antique Car Museum
- Cyclerion will present the results of a series of sickle cell disease patient and clinician interviews and a literature review conducted to better understand the symptoms that patients consider to be most important and relevant to their daily experience, as well as an assessment of existing patient-reported outcome (PRO) tools to evaluate how well each tool measures these symptoms.
- Abstract #PF731: A Strategy for the Measurement of Sickle Cell Disease Symptoms from the Patient Perspective
- Presenter: Funke Ojo, Senior Manager, Study Endpoints, Cyclerion
Friday, June 14, 5:30-7:00 p.m. CEST
- Location: Poster area
- Cyclerion preclinical research will also be presented demonstrating that its investigational sGC stimulator olinciguat was associated with improved blood flow and reduced inflammatory response caused by interactions between leukocytes and endothelial cells in a sickle cell disease model.
- Abstract #PS1521: The Soluble Guanylate Cyclase Stimulator Olinciguat Attenuates Leukocyte/Endothelial Cell Interactions In Berkeley SCD Mice
Huihui Li, Cell Biology Postdoctoral Fellow, Albert Einstein College of Medicine Saturday, June 15, 5:30-7:00 p.m. CEST
- Location: Poster area
Olinciguat is an investigational, orally administered, once-daily, vascular sGC stimulator designed for the treatment of sickle cell disease (SCD). SCD is an inherited red blood cell disorder that causes red blood cells to deform into a sickle shape, impacting blood flow to organs and tissues. These sickled red blood cells are more susceptible to hemolysis (rupturing). Upon red blood cell rupturing, nitric oxide is depleted due to arginase release and hemoglobin scavenging. Nitric oxide is an important regulator of blood flow, and the resulting deficiency of nitric oxide is believed to contribute to symptoms of SCD.
As sGC is a key node in the nitric oxide signaling pathway, olinciguat has the potential to address key symptoms and complications of SCD by addressing the disease’s underlying nitric oxide deficiency. The distribution of olinciguat to the vasculature as well as to organs with high blood flow, such as the kidney and lungs, may make it well suited for the potential treatment of SCD.
Olinciguat has been granted Orphan Drug Designation for SCD by the
Forward Looking Statement
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Source: Cyclerion Therapeutics, Inc.