Cyclerion Therapeutics Announces Publication of CY6463 Preclinical Data in Frontiers in Pharmacology
Series of preclinical studies demonstrate the therapeutic potential of CY6463, a first-in-class, CNS-penetrant sGC stimulator
Oral, once-daily CY6463 is being developed for neurological diseases associated with cognitive impairment
Cyclerion identified and developed CY6463 based on its ability to readily access the CNS and amplify nitric oxide‐soluble guanylate cyclase‐cyclic guanosine monophosphate (NO-sGC-cGMP) signaling in the brain. CY6463 was designed to address multiple pathophysiological features of neurodegenerative and neuropsychiatric diseases associated with cognitive impairment.
Extensive preclinical data from CY6463 and decades of research validate the crucial role of the sGC pathway in brain physiology and cognition. Across a range of preclinical models, administration of CY6463 resulted in physiologically relevant drug levels in cerebrospinal fluid (CSF) and led to improvements in neuronal function, neuroprotection, and cognitive performance. Together, these data further support the clinical development of CY6463 as a novel and potentially paradigm-shifting approach to the treatment of neurodegenerative and neuropsychiatric disorders.
Results from initial CY6463 clinical studies have demonstrated favorable safety and tolerability and pharmacologically relevant exposure in the CSF. In addition, CY6463 resulted in promising impacts on brain cortical oscillations, neuroinflammation, and other neurophysiological measures that support continued clinical development.
Cyclerion has an active Phase 2 study of CY6463 in participants with MELAS and the Company is planning to initiate additional Phase 2 studies in individuals with ADv and CIAS.
About Cyclerion Therapeutics
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Source: Cyclerion Therapeutics, Inc.